Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence
MyJA 3-1 57 PDF


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Purushotmanan, D. (2024). Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence. Malaysian Journal of Anaesthesiology, 3(1), 72–78. https://doi.org/10.35119/myja.v3i1.57

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Copyright (c) 2024 Darshelaan Purushotmanan


early pregnancy; misoprostol; pregnancy termination


Misoprostol is a synthetic prostaglandin E1 (PGE) analogue used for medical termination of pregnancy, managing miscarriage, inducing labour, cervical ripening, and treating postpartum haemorrhage. Generally, it is safe and well-tolerated, with dose-dependent adverse effects such as nausea, vomiting, diarrhoea, abdominal pain, fever, and headache that usually resolve within a few days. However, seizures are a rare complication, occurring primarily in patients with a history of epilepsy or a predisposition to seizures and is associated with high doses and rapid administration. This case report highlights the repercussions of a misoprostol overdose used for pregnancy termination, leading to seizures induced by hyperthermia. The first patient required temporary invasive ventilation and resuscitation but recovered, whereas the second patient receiving a lower dose, exhibited milder symptoms. Both patients received psychosocial counselling prior to discharge.

MyJA 3-1 57 PDF


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MyJA 3-1 57 PDF